Comparing Diagnostic Methods

ACG guidelines no longer include serology in H. pylori testing recommendations1

  • Serology is an inadequate method to test for H. pylori infection2
    • Sensitivity 85%, specificity 79%2
    • Cannot distinguish active H. pylori from past infection2

Some diagnostic labs have discontinued offering serologic testing for H. pylori3,4

Stool testing is associated with relatively low patient adherence5,6

In one study, more patients returned for a post-treatment UBT vs FAT (N=29)6

Stool Testing Post Treatment


Fecal occult blood

BreathTek® UBT for H. pylori aligns with guideline recommendations to test, treat, and confirm eradication of H. pylori infection.7

ACG guidelines recommend urea breath test (UBT), fecal antigen test (FAT), and endoscopy for eradication testing.7

Abbreviation: ACG, American College of Gastroenterology.

  • Chey WD, Wong BCY; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808-1825.
  • Vakil N, Fendrick AM. How to test for Helicobacter pylori in 2005. Cleve Clin J Med. 2005;72(suppl 2):S8-S13.
  • Mayo Clinic. Mayo Laboratories. Hot topic. Helicobacter pylori -- an update on diagnostic testing. Published February 1, 2016. Accessed August 21, 2017.
  • Quest Diagnostics. Helicobacter pylori Infection: Laboratory Support of Diagnosis and Management. Accessed August 21, 2017.
  • Ore L, Hagoel L, Lavi I, Rennert G. Screening with faecal occult blood test (FOBT) for colorectal cancer: assessment of two methods that attempt to improve compliance. Eur J Cancer Prev. 2001;10(3):251-256.
  • Cullen KP, Broderick BM, Jayaram J, Flynn B, O'Connor HJ. Evaluation of the Helicobacter pylori stool antigen (HpSA) test in routine clinical practice—is it patient-friendly? Ir Med J. 2002;95(10):305-306.
  • Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG clinical guideline: treatment of helicobacter pylori infection. Am J Gastroenterol. 2017;112(2):212-238. Accessed August 21, 2017.