Disease Progression

Know the symptoms and you can better assess which patients need testing.

Common symptoms of H. pylori infection may include:







Other symptoms may include early satiety, postprandial fullness, loss of appetite, nausea, flatulence, abdominal pain, vomiting, and halitosis.1-4

  • Acute infection is often asymptomatic1

The effects of untreated H. pylori infection can follow a clear, predictable progression.4

H. pylori infection is a common cause of gastric morbidity.5,6





Gastritis Chronic

Chronic Gastritis

Gastritis Atrophic

Atrophic Gastritis

Duodenal ulcers

Duodenal Ulcers

Gastric ulcers

Gastric Ulcers

H. pylori infection is the cause of most duodenal and gastric ulcers.4

  • Treating the infection has been shown to reduce ulcer recurrence and complications, including bleeding2
  • In NSAID* users, H. pylori infection is associated with a higher risk of peptic ulcer bleeding2
  • Guidelines recommend eradication of H. pylori infection prior to starting NSAID treatments7

*Nonsteroidal anti-inflammatory drug.

  • Meurer LN, Bower DJ. Management of Helicobacter pylori infection. Am Fam Physician. 2002;65(7):1327-1336.
  • Ables AZ, Simon I, Melton ER. Update on Helicobacter pylori treatment. Am Fam Physician. 2007;75(3):351-358.
  • H. pylori infection. Mayo Clinic website. http://www.mayoclinic.org/diseases-conditions/h-pylori/symptoms-causes/dxc-20318746. Published May 17, 2017. Accessed March 12, 2019.
  • Helicobacter pylori and peptic ulcer disease: the key to cure. Centers for Disease Control and Prevention website. http://www.cdc.gov/ulcer/keytocure.htm. Updated September 28, 2006. Accessed March 12, 2019.
  • Graham-Lomax K, Graham DY. Contemporary Diagnosis and Management of H. pylori-associated gastrointestinal diseases. 3rd ed. Newtown, PA: Handbooks in Health Care Co; 2005.
  • Houghton J, Wang TC. Helicobacter pylori and gastric cancer a new paradigm for inflammation-associated epithelial cancers. Gastroenterology. 2005;128(6):1567-1578.
  • Malfertheiner P, Megraud F, O’Morain CA, et al; European Helicobacter Study Group. Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report. Gut. 2016;0:1-25. doi:10.1136/gutjnl-2016-312288.